Fallbericht Gynäkologie und Geburtshilfe Offener Zugang

Abstrakt

Cracking the Molecular Mechanisms of Oridonin-Induced Reproductive Toxicity: A Multi-Omics Method Using the Wnt/β-Catenin Signaling Pathway as a Target

Qibin Gao

Oridonin, a bioactive diterpenoid isolated from the traditional Chinese medicinal herb Rabdosia rubescens, has garnered attention for its anti-cancer, anti-inflammatory, and anti-microbial properties. Despite its therapeutic potential, recent studies have indicated that oridonin may induce reproductive toxicity, raising concerns about its safety, especially in long-term use. Understanding the molecular mechanisms underlying oridonin-induced reproductive toxicity is crucial for mitigating its adverse effects and harnessing its therapeutic benefits. The Wnt/β-catenin signaling pathway plays a critical role in cell proliferation, differentiation, and development. Dysregulation of this pathway has been implicated in various reproductive disorders. Combining advanced omics technologies—proteomics, metabolomics, and epigenetics—offers a comprehensive approach to uncovering the intricate molecular networks involved in oridonin-induced reproductive toxicity, particularly focusing on the Wnt/β-catenin signaling pathway.