Zeitschrift für Neuroonkologie und Neurowissenschaften Offener Zugang

Abstrakt

Culture Insights of Cellular Mechanisms of Glioblastomas Growth

Valerii Matcovschii, Valentin Gudumac, Dan Lisii, Lilia Andronache

At present, glioblastomas of the brain are incurable tumours and the new developments of clinical neurosurgery, radiation therapy and chemotherapy do not solve the issue. Studying the cellular and subcellular growth mechanisms of the initial glioblastoma cells taken from tumours during neurosurgery and cultivating said cells for 3-6 months, allows us to put forward a relatively new hypothesis about the amitotic division of the glioblastoma cells. It is important to note that the tumour growth occurs via the transfection and expression of fragments of proteins and nucleic acids produced by the glioblastomas into the healthy contractile glial cells. This hypothesis is indirectly confirmed by conducing experimental studies with the introduction into the cell culture of polymerase, adenovirus of the AstraZeneca vaccine, as well the visual data obtain during magnetic resonance imaging (MRI) to observe the dynamic and character of the growth of glioblastomas in the brain.