R. Rohit, P. Narayana Raju, Mounica Chityala, R. Naveen, Macha Ramu, and G. Nagarjuna reddy
An attempt was made to optimize an erosion matrix based drug delivery system for Phenytion sodium (PhNa) using a combination of Cetostearyl alcohol (CSA) and Stearic Acid (SA). The ratio of drug to level of CSA and SA and the effect of Plasdone (PVP K30) as pore former on the in vitro dissolution profile were evaluated using a 23 Design of experiments. The USP dissolution Test 1 specification for Phenytion Sodium Controlled Release tablet was considered for the optimization study.
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