Zeitschrift für Pharmazie und pharmazeutische Forschung Offener Zugang


Evaluation of Limonene β-Amino Alcohol Derivatives for Synergistic Antibacterial activity against Staphylococcus aureus

Weerachai Phutdhawong1, Benjamart Ruangrote2, Tongchai Taechowisan3, Waya S. Phutdhawong2*

Limonene β-amino alcohols were synthesized and evaluated for their antimicrobial activity against Staphylococcus aureus Sp3, the ciprofloxacin resistance stain through the expression of the NorA efflux pump, and synergistic activity were evaluated by checkerboard and time-kill curves. The results showed that most of the synthesized compounds were found to exhibit potent activity. Synergistic investigation of combinations of the synthesized compounds with ciprofloxacin clearly suggested that compounds 6b and 6h exhibited enhanced synergistic effects (FICI of 0.25) which could provide novel therapeutic strategies for the treatment S. aureus infection.