Sadhu Nelson Kumar, Kandula Ravindra Reddy, Kothapalli Bonnth Chandra Sekhar and Rakhal Chandra Das
Cleome gynandra has been used widely in Indian indigenous system. In the present study the hepatoprotective effect of methonolic extract of C. gynandra (MECG) was investigated against carbon tetrachloride (CCl4) induced hepatocellular injury in wistar rats. The various parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TB) were studied in the present study. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Administration with MECG (200 and 400 mg/kg, P.O.) for 14 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, alkaline phosphatase and total bilirubin. The histopathological studies in the liver of rats also supported that cleome gynandra extract markedly reduced the toxicity of CCl4 and preserved the histoarchitecture of the liver tissue to near normal. Thus, the results suggest that cleome gynandra extract acts as a potent hepatoprotective agent against CCl4 induced hepatotoxicity in rats.
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