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Immortalization of Human Adipose-Derived Stem Cells as Useful Tool to Produce Cell-Secreted Paracrine Factors for Future Applications in Cell Therapy and Regenerative Medicine

Balducci L, Saldarelli M, Alessandri G

Multipotent mesenchymal stem cells (MSCs) were isolated for the first time by Friedstein from adult bone marrow. During the following years, MSCs were identified and isolated from other tissues such as trabecular bone, skeletal muscle, skin and umbilical cord. Since from their discovery, MSCs became an attractive field of research for Cell-based Therapies (CT) and Regenerative Medicine (RM).