Abdorrahman Tofighi Rad, Amin Hassanzad, Mohammad Aryaie and Fozieh Bakhsha
Preoperative anxiety and postoperative pain are great concern to parents. The objectives of this experiment were to evaluate and compare postoperative effect of oral clonidine on surgical pain with Mepridine analgesia in children. We also compared the influence of these two different medication regimens on hemodynamic status and oxygen saturation (SPO2) of patients during and after surgery. This double-blind, prospective, randomized study, was performed on 44 children, ASA status I or II, aged between 1 and 3 years, that underwent elective herniotomy. The patient was elected randomly into two groups: group C (Clonidine) (n = 22) received clonidine 4 μg/kg given orally 60 min prior to anesthesia induction and, group M (Mepridine) (n = 22) received mepridine 0.5 mg/kg after surgery. Degree of Postoperative analgesiawas assessedby using FLACC scalesystem .Preoperative oral clonidine at 4μg/kg reduced postoperative pain score and requirement for supplementary analgesic in children compared with postoperative Mepridine as analgesia. The results showed no significant difference on hemodynamic status and oxygen saturation (SPO2) between the two groups .According to the hypotensive effects of clonidine, not significant difference in blood pressure and heart rate were observed in the two groups.
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