Deepti gaurav, Shabad Preet and K. K. Dua
The present study was planned to elucidate the role of dietary nutrients alone and their combination in the modification of toxicity of cadmium with emphasis on vital organ dysfunction. The animals were randomly divided into seven groups where the control group (Group I) receiving physiological saline (p.o.) and group II was administered with cadmium chloride (0.1mg/kg) only group III, IV, V, VI and VII receiving 2.5 mg/kg dietary nutrients i.e. N-acetyl cystiene, methionine, melatonin, Vit-B1 and their combination. All dietary nutrients were administered orally for 21 days with a concomitant subcutaneous (s.c.) cadmium treatment. It was shown that exposure to cadmium induced a significant increase in urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum whereas decrease in haematocrit value (Htc), haemoglobin concentration (Hb) and blood glutathione (GSH) in blood of rats. Administering of dietary nutrients alone or their combination with cadmium chloride resulted increase in GSH level in blood and statistically significant decrease in AST, ALT, urea and creatinine level in serum as well as decreased Cd accumulation in liver and kidney in relation to animals receiving cadmium chloride alone.
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