Zeitschrift für Pharmazie und pharmazeutische Forschung Offener Zugang

Abstrakt

Synthesis and Cytotoxic Screening of Fused Analogues of Dihydropyrimidinones against Hepg2 Cancer Cell Lines

Richard Soni, Ramandeep Kaur Brar, Rupinder Kaur Gill and Jitender Bariwal

10In the past decades, Biginelli-type dihydropyrimidones have received an extensive attention due to their interesting pharmacological properties with heterocyclic scaffolds. In this article, we have synthesized a series of fused analogues of Biginelli’s dihydropyrimidinone derivatives (RS-6 to RS-15). IC50 values of synthesized compounds against the proliferation of human hepato cellular carcinoma (HepG2) cell lines were determined through MTT assay. Compounds RS-10 (IC50=87 ± 0.2 μg/mL) & RS-15 (IC50=78 ± 3.7 μg/mL) showed most potent activity. Also compounds RS-7 (IC50=124 ± 3.2 μg/mL) & RS-12 (IC50=128 ± 1.9 μg/mL) showed significant cytotoxic activities against HepG2 cancer cell lines.