Ezzat H. Zimam
New series of 2-heterocycle-substituted benzimidazole having a pyrazolo [3, 4-d] pyrimidine nucleus have been synthesized by reacting 2-(chloromethyl) benzimidazole with hydrazine hydrate to form compound (1). The vital compound in this synthesis 1- ((benzoimidazol-2-yl)methyl)-3-methyl-pyrazol-5-one was obtained by reacting compound (1) with ethyl acetoacetate, and was used in the Biginelli multi-component cyclo condensation reaction with eight derivatives of benzaldehyde in presence of urea to form pyrimidine derivatives (3-10). The products were characterized by C.H.N analyses, I.R spectra and 1HNMR spectrum. Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative). Some the compounds showed high inhibition activity against bacteria.
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