Europäisches Journal für Experimentalbiologie Offener Zugang

Abstrakt

The effect of chronic ingestion of crude garcinia kola on the histology of the liver

Charity U Osifo, Uwaifoh Akpamu, Charlse I Idehen, Williams A Adisa and Kerry E Azeke

Different quantities of Garcinia kola in form of determined doses in mg/kg body weight was given to different groups of rabbits daily for a period of six weeks, to assess possible adverse effects of chronic administration on the histology of the liver. 1200mg/kg, 1500mg/kg and 1800mg/kg of the reconstituted powdered Garcinia kola were administered to the rabbits in the test groups B, C and D respectively while A (control) received normal saline. Slide photomicrographs of the control (group A) shows normal histological hepatocytes. Although photomicrographs of the tests groups (B, C and D) presented mild cellular edema, this was not of any pathological significant because it was also observed in the control (group A). The elicitation of no observable histo-pathological effects by Garcinia kola on the histology of the liver is a reflection of its hepatic safety in healthy condition. However, it toxic dose requires investigation and thus the needs for further studies.