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Abstrakt

The iron woman: mamographic density, physical activity, and breast can- cer

Noelle L. Cutter

Physical activity is a modifiable lifestyle risk factor in prevention of breast cancer. It is well established that regular physical activity is associated
with a reduced risk of breast cancer. A meta-analysis found that physically active women have 12% reduced risk of breast cancer compared to
the inactive women. Mammographic density (MD) is a strong risk factor for breast cancer. Physical activity been hypothesized to reduce breast
cancer risk through several mechanisms, including weight loss, obesity prevention, reduced sex hormone exposure, reduced levels of insulin and
insulin-like growth factor exposure, induced immune system function, and mechanism of DNA repair. Some of these factors, such as alteration in
the metabolism of endogenous hormones, are suggested to influence MD. MD is increasingly being used as a biomarker of breast cancer risk, as
it is one of the strongest risk factors. MD refers to the amount of radiologically dense breast consisting of epithelial or stromal tissue that appears
light on a mammogram, whereas fat tissue appears dark on a mammogram. The goal of our study is to investigate a link of regular physical activity
with MD and risk factor association to breast cancer.