A.A. Komar, D.A. Skuratovskaia, M.A. Vulf, L.S.Litvinova,
Statement of the Problem: The anti-inflammatory cytokine interleukin-10 (IL10) may play a protective role in type 2 diabetes (T2D). The Wnt5a signaling pathway regulates the production of a wide range of cytokines in stellate cells of the liver, so we suggest a relationship between the expression of the WNT5a gene in the liver and the content of IL-10 in the circulation in obese patients with and without T2D. Methodology & Theoretical Orientation: Serum glucose levels were determined on a biochemical analyzer; the concentration of IL10 in blood plasma - by flow fluorimetry; WNT5a gene expression level - by PCR; quantitative content of protein WNT5A – by Western Blotting. Findings: Expression of the gene Wnt5a in the group of obese patients without diabetes increased by 1.7 times (p<0.05); the group of obese patients with diabetes increased by 1.47 times (p<0.05).
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